TEDE Coleção:
http://tede2.pucgoias.edu.br:8080/handle/tede/2087
2024-03-28T10:44:51ZCésio 137: revisão integrativa do biomonitoramento genético de pessoas expostas à radiação ionizante no acidente radiológico de Goiânia, no período de 1988 a 2021
http://tede2.pucgoias.edu.br:8080/handle/tede/4827
Título: Césio 137: revisão integrativa do biomonitoramento genético de pessoas expostas à radiação ionizante no acidente radiológico de Goiânia, no período de 1988 a 2021
Autor: Uchoa, Elza Maria Gonçalves Santos
Primeiro orientador: Cruz, Aparecido Divino da
Abstract: Considered as a serious radiological accident, categorized as level 5 on the INES scale (International Nuclear Event Scale), the accidental rupture of the radioactive capsule of Cesium-137 in the radiological accident in the city of Goiânia in 1987, where people were directly exposed and indirectly to the radioactive material, so a monitoring of the physical, psychological and biological health of these people started immediately after the event. Knowing that the ionizing radiation according to the dosage received by the exposed individual has important effects at the cellular level and that significantly impact the DNA. The objective of this work was to carry out an integrative review of the data of the genetic monitoring of the population exposed to ionizing radiation of Cesium-137 in Goiânia. The methodology was an integrative literature review of articles published between 1988 and 2020, using the descriptors DECs / MESH: Accident, Brazil, and Cesium; through the PubMed, Scopus and Lilacs databases. The analysis of the 26 selected articles allowed the identification of the main researchers and their countries, the journals that published these studies, the main biomarkers and techniques used in the observation of the potential of ionizing radiation for DNA damage and other cellular anomalies, at the somatic and germinative. We conclude the importance of the biomonitoring of the Goiás population exposed to ionizing radiation by cesium 137, with the production of studies that demonstrated that acute and chronic effects can impact human genetic health.
Instituição: Pontifícia Universidade Católica de Goiás
Tipo do documento: Dissertação2021-05-27T00:00:00ZAnálise do polimorfismo do gene CYP3A5 em amostras de pterígio em Goiânia - Goiás
http://tede2.pucgoias.edu.br:8080/handle/tede/4826
Título: Análise do polimorfismo do gene CYP3A5 em amostras de pterígio em Goiânia - Goiás
Autor: Araújo, Letícia Claudino
Primeiro orientador: Costa, Iasmim Ribeiro da
Abstract: Pterygium is defined as an external eye disease, caused by abnormal growth of fibrovascular tissue. It has a triangular shape that starts from the nasal bulbar conjunctiva and can cover the cornea. Several factors are associated with the development of the pterygium, like physical aspects - heat, dust, particles of the atmosphere - and immunological mechanisms such as the reorganization of the extracellular matrix, cytokines, growth factors, angiogenesis, apoptosis, among others. Studies show that the expression of enzymes of the CYP1A1 family in the pterygium correlates with allelic variation and can be used as an independent risk marker for disease. This study seeks to analyze the genotypes of the CYP3A5 gene in relation to the pterygium. It was observed that the most frequent genotype in the population in Goiânia is heterozygous CYP3A5 * 1 / * 3. The CYP3A5 genotype is not related to the risk factors analyzed: gender, ethnicity, family history of ocular pathologies, occupational exposure, smoking and alcohol.
Instituição: Pontifícia Universidade Católica de Goiás
Tipo do documento: Dissertação2021-03-02T00:00:00ZAvaliação da diversidade genética de Prochilodus lineatus (Valenciennes 1836) no Rio Claro, Goiás, Brasil
http://tede2.pucgoias.edu.br:8080/handle/tede/4818
Título: Avaliação da diversidade genética de Prochilodus lineatus (Valenciennes 1836) no Rio Claro, Goiás, Brasil
Autor: Sousa, Herida Samaya Gonçalves de
Primeiro orientador: Cruz, Alex Silva da
Abstract: Hydroelectric energy is the most used source of renewable energy which contributes significantly to the generation of global energy, and it is also often considered as a source of clean energy due to the reduction of effluent pollution. However, the dams of hydroelectric plants prevent the natural flow of the river which affects the entire local ecosystem, especially the species that migrate for reproductive purposes. Knowing the genetic diversity of populations is important to develop conservation actions that aim to reduce the risk of extinction Because of the present scenery, this study aims to make an analysis of the genetic diversity using microsatellite molecular markers of the populations of Prochilodus lineatus from Rio Claro in the city of Caçu (Goiás, Brazil Overall, 63 specimens were collected at five points distributed along the main channel of the Rio Claro from 2012 to 2014. The specimens were subdivided into three populations (A, B and C) according to the barriers present in the river. These individuals were analyzed using five loci of microsatellite molecular marker. The analysis of the measure of exclusion of paternity and likelihood of identity, the values Q = 0.999 and PI = 9.507 x 10-11 were found, indicating that the five loci performed in the study are efficient for population genetic studies, because they were able to discriminate between individuals. On average, 15 alleles were identified per locus. The population average of the observed heterozygosity (0.5378) was below the population average of the expected heterozygosity (0.9176), with the presence of inbreeding resulting from the reproductive system Fis (0.4625). The Fst value was low (0.016), therefore, it was significant (p≤0.05%), indicating a population subdivision, corroborating with the results of the Bayesian analysis that showed two genetic groups, when verifying the analysis of genetic divergence. The first group is the population (A and B) and the other group is the population (C). However, there is a gene flow between populations A and B, on the other hand, the population C is genetically isolated, possibly due to the fact that it is located between two anthropic barriers. The populations presented a low genetic diversity and high inbreeding, which may be related to the population subdivision found in the river. This study was important to indicate to conservation programs that the species P. lineatus may be possibly suffering impacts caused by the barriers present in the course of Clear river
Instituição: Pontifícia Universidade Católica de Goiás
Tipo do documento: Dissertação2021-05-31T00:00:00ZO estado da arte dos estudos sobre os aspectos genéticos associados ao Transtorno do Espectro Autista
http://tede2.pucgoias.edu.br:8080/handle/tede/4467
Título: O estado da arte dos estudos sobre os aspectos genéticos associados ao Transtorno do Espectro Autista
Autor: Chaves, Rafael Borges
Primeiro orientador: Rodrigues, Flávia Melo
Abstract: The objective of this study was to characterize and quantify published articles on
genetic polymorphisms associated with Autistic Spectrum Disorder (ASD), through a
scientometric analysis. A survey of the articles was done through the Scopus database using
the keywords: "Autism * Spectrum Disorder and gene". In 17 years, 1040 articles published
on genetic polymorphisms related to ASD. There was an increase in the number of these
publications over time (p <0.0001). On average, the impact factor of the journals was 5.76
with 10.84 collaborators per article and cited 37.24 times. The impact factor tends to increase
with the number of citations (p <0.0001) and with the number of collaborators (p = 0.0014).
The number of citations tends to increase in studies with more employees (p <0.0001) and
decrease in more recent articles (p <0.0001). Medicine was an area of knowledge that stood
out in the publications and Brazil ranks 17th in the ranking of the countries that published the
most on genetic polymorphisms related to ASD. A total of 717 TEA-related polymorphic
genes were identified and of these 15 genes were studied in 30 or more articles. Therefore, it
is noticed that the scientific community has shown interest in developing research related to
genetic polymorphisms associated with ASD.
Instituição: Pontifícia Universidade Católica de Goiás
Tipo do documento: Dissertação2019-03-27T00:00:00Z