CARBAMAZEPINA NO ESTADO SÓLIDO E SUA SUSCEPTIBILIDADE POLIMÓRFICA

Abstract

Many pharmaceutical products are in solid state for reasons of stability or ease of handling during the stages of drug development. The polymorphism is the crystallization of the same substance in different crystalline architectures. This phenomenon is very common in pharmaceuticals and is associated with differences in packing arrangements of crystalline. The presence of different crystalline forms for the same drug can change some of its physicochemical properties such as solubility, which can directly affect their bioavailability and therapeutic efficacy. In this context, carbamazepine has served as a model compound for the study of polymorphism, where an analysis of its structural diversity has sought to evaluate the susceptibility polymorphic. Significant differences between the polymorphic forms of anhydrous carbamazepine were characterized by spectroscopic methods and difratometria, especially the X-ray diffraction, the important structural information provided. Where Polymorphic susceptibility to the more stable form can be observed due to several factors including the energy content is highlighted.