DETECÇÃO E GENOTIPAGEM DE HPV EM CARCINOMAS DE CAVIDADE ORAL E OROFARINGE.

Abstract

The human papillomavirus (HPV) has been associated with the risk and prognosis of oral cavity and oropharynx carcinomas. This study aimed to estimate the prevalence and genotype distribution of HPV 16 and 18 in oral cavity and oropharyngeal carcinomas, as well as their associations with clinical and histopathological factors of tumors. It is a retrospective descriptive study, with gathered data analysis of 82 medical records and paraffin blocks containing specimens of oral cavity carcinomas and oropharynx diagnosed at the Hospital Araújo Jorge (HAJ), in Goiânia-GO, between 2005 and 2007. The chain reaction polymerase (PCR) was used for HPV detection and genotyping. Among the 82 evaluated patients, 78% were male. The average age of patients was 58 years. Risk factors, like smoking (78 %) and ethylism (70.8 %), were registered in the studied group. HPV DNA was detected in 21 cases (25.6%; 95% CI: 16.9 to 36.6) of which 33.3% were HPV 16 and 14.3% HPV 18. The presence of metastases lymph node and deaths were less common in tumors with HPV, suggesting a better prognosis for these cases, however, the differences between the groups were not statistically significant. The data described in the present study, regarding the presence of the HPV genome, and the high risk oncogenic genotypes, HPV16 and HPV18, in oral cavity and oropharynx carcinomas highlights the importance of vaccination against HPV in such tumours.