AVALIAÇÃO DAS ATIVIDADES ANGIOGÊNICA, GENOTÓXICA E ANTIGENOTÓXICA DO ÓLEO DA CARAPA GUIANENSIS (ANDIROBA).

Abstract

According to WHO, about 80% of world population, somehow, makes use of medicinal plants as medicine, and only 30% is done by medical indication. Currently the intense search for alternative therapies such as herbal medicine, is due to the inefficiency of some synthetic products, the high cost of allopathic and the search for less harmful to body treatments. The plant compounds responsible for serving in combat diseases are the secondary metabolites. The most outstanding terpenes; phenolic compounds and nitrogen compounds. In Brazil, the extracted oil of Carapa guianensis seed has been used as an herbal medicine, is applied in wound healing, treatment of febrile diseases, inflammation and pain. Its main constituents and possibly responsible for its biological activity are the fatty acids and limonoids compounds. In view of the wide and use and Andiroba oil plant characteristics, this study aimed to investigate the possible angiogenic, genotoxic and antigenotoxic activities. To assess angiogenesis was used the experimental model of MCA. Genotoxicity and antigenotoxicity tests were carried out in vivo, in mice through the micronucleus test. The test results on the MCA indicated that the oil caused a significant increase in vascular network (p<0.05) compared to neutral controls and inhibitor. In the micronucleus test, the effect of the oil antigenotoxic at doses of 250, 500 and 1000 mg kg b.w. Was observed in all treatment groups, since the number of micronuclei was lower (p<0.05) in the positive controls CP and MMC. With the methods and conditions employed, the results of this study suggest that the andiroba oil is not genotoxic and has important potential Physiotherapy, with angiogenic and antigenotoxic activity.