INFLUÊNCIA DO BARBATIMÃO(Stryphnodendron adstringens)NA ANGIOGÊNESE E GENOTOXICIDADE.

Abstract

The barbatimão (Stryphnodendron adstringens) is a medicinal plant, rich in tannins, found in the cerrado, which has anti-inflammatory, analgesic activity and a protective activity of gastric mucosa. In this work we evaluated the angiogenic activity and result from antiangiogenic, genotoxic and non-genotoxic of the barbatimão bark aqueous solution. Data from recent studies of the angiogênise using the CAM of hens egg to the barbatimão were not found in the literature. The barbatimão shells for the preparation of ASB (aqueous solution of barbatimão) were acquired in the city of Goiânia. Were used 30 grams of crushed shells to one litre of water. Angiogenic activities and result from antiangiogenic were evaluated by the experimental method of the corioalantoide membrane (CAM) and as positive control was used the Regederm product, which features angiogenic activity known. Genotoxic activity was evaluated from the barbatimão from aqueous solution using experimental model the micronucleus test in bone marrow of mice, and non-genotoxic activity was evaluated by the simultaneous treatment of the ASB and the compound known to be genotoxic Mitomycin C (MMC). The presented ASB tests, was considered genotoxic, angiogenic and features not non-genotoxic on concentration tested compared with the controls. The ASB presented a high vascularization in MCA (50.4) compared with the positive control (52.9). The dose of the barbatimãos peel solution (30 mg.ml -1) analyzed presented difference (p<0,05) at the EPCMN frequency relative to the negative control group.Comparing the frequency of dose EPCMN SABMMC concurrent treatment with the positive control, there was no significant difference (p>0,05). The results were promising, cooperating with future research for developing new medicines. It is noticed that the genus presents promising active principles for the development of new herbal medicines, that becomes necessary more studies and research for consumer safety.