PESQUISA DE HEMOGLOBINOPATIAS E TALASSEMIAS EM PACIENTES PORTADORES DE LÚPUS ERITEMATOSO SISTÊMICO.

Abstract

15 Systemic Lupus Erythematosus is a quintessential multigenic and multifactorial disease, with remarkable clinical and pathogenic complexities. The causes of the SLE total are not known, but it knows that ambient and genetic factors are involved. The observed clinical manifestations in patients to take hold of the SLE are diversified as fatigue, indisposition, slimming, arthritis, fever, nephritis, vasculitis, and anemias. Amongst them you various observed clinical manifestations in lupus patients, the anemias in them call the attention mainly when prevalence 52.5% of the patients with RBC index suggestive of anemias is observed in our study. This picture of anemia normally is observed in lupus patients, but the hereditary anemias, especially the hemoglobinopathies and thalassemias, are the most common of the human genetic alterations and its frequency in the Brazilian population is very variable, have few carried through studies of prevalence in the populations attacks for SLE. In an attempt to evaluate the prevalence of the hemoglobinopathies and thalassemia in the population with systemic lupus erythematosus. We studied 80 blood samples of patients with systemic lupus erythematosus in the Hospital das Clinicas de Goiânia-Brazil had been studied. Laboratories tests had been used but not molecular tests. The frequency of the alterations of the hemoglobin was 8.75%, found in 7 patient. Of those alterations, the more prevalent was the thalassemia alpha, found in 4 patient, corresponding to a frequency of 5.0% of the studied population. The second more frequent alteration was the heterozigous for the hemoglobin S, found in 2 patients, corresponding to 2.5% of the population. The third alteration was the heterozigous for the hemoglobin C, found in 1 patient 1.25%. No case of homozigose was found in the present study. This study demonstrates hemoglobinopathies and thalassemia be include between several cause of anemia in SLE.