ANÁLISES COMPARATIVAS DAS PROBABILIDADES DE PATERNIDADE OBTIDAS A PARTIR DE DIFERENTES BANCOS DE DADOS POPULACIONAIS DO BRASIL.

Abstract

For human identification purposes in Forence area, the United States created the database (DB) of DNA Index System Combined (CODIS), containing 13 loci: CSF1PO, FGA, TH01, TPOX, VWA, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51 and D21S11. Then the DBs of the markers of the Y-STR X-STRs haplotypes were created. Comparison of the obtained data was conducted from allele frequencies (AF), paternity index (PI) by marker and paternity probabilities (PPs) obtained from nine BD population, one of those national (BR), using 241 cases containing the PP 99.99 using 13 loci STRs (CODIS) and 2 more STRs markers of Penta D- and E, granted by the BDs of Núcleo de Pesquisas Replicon, of the Pontifícia Universidade Católica de Goiás (PUC - GO) and LaGene, Laboratório Central de Saúde Pública (SES - GO). 241 cases were analyzed in Trio (alleged father, son and progenitor) and Duo (alleged father and son) situations, using 13 STRs markers (CODIS) by Bayes theorem and the Likelihood Ratio (LR). The results were submitted to the Kruskal-Wallis, chi-square, Spearman correlation and Fishers exact tests and SPSS software (2010). Static analysis of RV cases containing the Trio resulted in 1,148 results PPs 99.99% and 21 results PPs <99.99%, and in a position to Duo 1686 results with PPs 99.99% and 483 results PPs <99.99%. The analysis of the IP average of each marker showed the D21S11 of STRs markers and FGA with the highest power of inclusion and TH01 and D3S1358 with the lowest power of inclusion. The PPs did not show significantly different, containing mostly positive correlation, of moderate to strong, between 8 BDs compared to the BR population databases. This study demonstrated the statistics interference that each allele frequencies DB can have in PP calculations using only 13 loci of genetic, thus making it more significant in cases Duo situation. According to the information available in databases of gene frequencies of the different geographical regions of Brazil, it became possible to conclude that the allele frequencies obtained and the IPs per marker and PPs obtained, suggest strong similarities to those found in the national database.