POLIMORFISMOS GENÉTICOS ASSOCIADOS À PRÉ-ECLÂMPSIA: TENDÊNCIAS NA PRODUÇÃO CIENTÍFICA

Abstract

Preeclampsia is an exclusive pathology of pregnancy, characterized by hypertension associated with proteinuria. It occurs after 20 weeks of pregnancy. Its prevalence is 8% in singleton pregnancies and 14% in twin pregnancies. It has an unknown etiology up to date. It is currently accepted that genetic factors are important in the development of preeclampsia due to the increased risk in women with family history of preeclampsia, with a history of preeclampsia in a previous pregnancy and on those with partners whose mothers or previous partner have a history of preeclampsia. Preeclampsia figures as the main cause of maternal mortality in Brazil and for this reason, its study is of great interest to public health. The objective of this study was to identify the scientific publications about on preeclampsia and possible associations with genetic alterations during the period of 2005-2015, in the Scopus platform. Different approaches were carried out to evaluate the articles, using as a method, scientometrics. As a result, we observed a significant increase in research and publications on polymorphism in preeclampsia, with a prevalence of authors, publications and institutions of developed countries and a significant association of 45 polymorphisms of genes with preeclampsia. We observed that polymorphisms of genes and the relationship between them is not clear and needs further studies to obtain more results that are consistent.