AVALIAÇÃO DAS ATIVIDADES ANGIOGÊNICA/ANTIANGIOGÊNICA E MUTAGÊNICA/ANTIMUTAGÊNICA DO ÓLEO ESSENCIAL DA Lantana camara (Cambará)

Abstract

The Lantana camara, popularly known as “Cambará”, is a plant that has many medicinal uses and biological properties as anti-inflammatory, wound healing, antioxidant, analgesic, antitumor actions, among others. Despite having many beneficial activities, the Lantana camara also has ill effects and is considered embryotoxic and hepatotoxic in some animals. On this, the present work aims to evaluate the angiogenic activity of the essential oil of Lantana camara (O.E.L.C) using the chick embryo chorioallantoic membrane (CAM) assay; evaluate the mutagenic and antimutagenic, anticytotoxic and cytotoxic, genotoxic and antigenotoxic activities of O.E.L.C using the micronucleus test in hematopoietic bone marrow of mice and comet assay in blood cells of mice. In the evaluation of angiogenic activity at MCA the O.E.L.C was tested at a concentration of 4,25 mg/ml. In the evaluation of mutagenic, cytotoxic, genotoxic activities the mice were individually treated with intraperitoneal doses of O.E.L.C (300 mg/kg, 600 mg/kg, 1200 mg/kg). In the evaluation of antimutagenic, anticytotoxic, antigenotoxic activities the mice were treated with doses of O.E.L.C (300 mg/kg, 600 mg/kg, 1200 mg/kg) together with doxorubicin 2 mg/kg. The results of the evaluation the angiogenic activity in the CAM show that O.E.L.C significantly increased the formation of new blood vessels when compared to the positive control (p < 0.05). The results evaluation of mutagenic and cytotoxic activities showed that the O.E.L.C exhibited mutagenic, cytotoxic and genotoxic effects at doses of 600 mg/kg and 1200 mg/kg when compared to the negative control (p < 0.05). The results of the evaluation of the antimutagenic, anticytotoxic and antigenotoxic activities showed that O.E.L.C did not exhibited antimutagenic, anticytotoxic and antigenotoxic effects (p > 0.05) for any of the administered doses when compared to the positive control. It is concluded that the experimental conditions of the present research the essential oil of Lantana camara (O.E.L. C) exhibited angiogenic activity, and mutagenic, cytotoxic and genotoxic activities.