Avaliação das atividades genotóxicas/antigenotóxicas da brugmansia suaveolens (trombeta)

Abstract

The use of psychoactive substances has been increasingly among the population, several individuals have sought alternative sources of substances that provide effects such as: visual hallucinations and mood changes. Brugmansia suaveolens (Trumpet), a plant commonly found in Brazil, is widely used by these users, whether in religious cults, indigenous tribes, or by younger individuals. This vegetable has the ability to interact with the serotonergic and dopaminergic receptors inducing the user, potent hallucinogenic effects. There are few reports of genotoxicological and mutagenic studies using this plant. Therefore, the present study aimed to evaluate the possible genotoxic/antigenotoxic and cytotoxic/anticytotoxic activities through the micronucleus test in hematopoietic bone marrow of mice. We selected 48 animals of both sexes and divided into 8 groups, 3 for genotixicity tests (250, 500 and 1000), 3 for antigenotoxicity tests (250, 500 and 1000) and 2 groups (negative and positive control). It was observed that the groups that received the three doses (250, 500 and 1000 mg / kg) of the crude aqueous solution of the plant had a higher number of micronucleus in relation to the negative control. The test dose (500 and 1000 mg / kg) of the antimutagenicity group showed no difference in relation to the positive control. The crude aqueous solution of Brugmansia suaveolens through the micronucleus test showed genotoxic, mutagenic and cytotoxic activity at doses of 250, 500 and 1000 mg / kg and absence of antigenotoxic, antimutagenic or anticytotoxic activity at doses of 500 and 1000 mg / kg.