Fatores associados à velocidade de onda de pulso em uma coorte de pacientes com fatores de risco cardiovasculares

Abstract

(VOP), obtained by the central blood pressure measure (MCPA). Objective: to analyze the factors associated with PWV in patients with CVD. Methods: Retrospective cohort study performed by means of patient charts. Data regarding the presence of cardiovascular risk factors (CVRF), medication dosage and blood laboratory test results, carotid doppler and echocardiogram were taken from the medical records. Participants were divided into two groups, according to the initial OPV value: G1 those with OPV <10m/s and G2 with OPV > 10m/s. The possible associated factors were evaluated after the interval of one to two years of the first MCPA measurement. In order to compare the socioeconomic, clinical and clinical variables of G1 and G2 patients in the initial evaluation, chi-square or Fisher and unpaired t-test. Logistic regression analysis was performed to verify the association of CVRF, class of medications, blood pressure control, laboratory and imaging tests with increased OPV (OPV >10m / s). Results: A total of 101 patients were evaluated, 56.0% female. The prevalence of systemic arterial hypertension (SAH) of 80.2% (n = 81), dyslipidemia (DLP) was 65.6% (n = 66), 36.6% (n = 37) and diabetic testis mellitus 18.0% (n = 18). In the initial evaluation, 81.2% of the patients had POC <10 mm / s (G1) and 18.8% had a POC greater than 10 mm / s (G2). The two groups were homogeneous with respect to socioeconomic and clinical variables with the exception of age that was higher in G2 75.4 (SD: 5.0%) than in G1 51.9 (SD: 12.7) (p, 0.001) . Statin was most frequently used by patients with OPV <10m/s. Systolic blood pressure and central and peripheral pulse pressure were higher in G2. The odds of presenting PWV > 10m were higher in patients who used statin (OR: 4.03; p = 0.013); (OR: 4.03, p = 0.004) and in those who used three antihypertensives (OR: 11.4, p = 0.045). When the model was adjusted for age, only statin use remained associated with increased OPV (OR: 4.04; p = 0.032). There was a correlation between age and PWV. Conclusion: The increase in OPV was positively associated with pa- tients using statin. VOP shows a strong correlation with age (r = 0.9475, p <0.001)