AVALIAÇÃO DAS ATIVIDADES ANGIOGÊNICA/ANTIANGIOGÊNICA, MUTAGÊNICA/ANTIMUTAGÊNICA DA FOSFOETANOLAMINA

Abstract

The malignant neoplasms are a public health problem worldwide, being the biggest cause of premature mortality of the planet. In Brazil, in 2012, more than 200 thousand people died, and it is estimated that within 20 years, there will be an increase of approximately 70% of new cases. Therefore, since a long time, the alternative therapies constitute a way of promoting "miracle" for the cure of cancer. However, the miraculous empiricism has no scientific basis and not enough documentation to prove the efficacy and quality these substances used in this self-treatment. Thus, the fosfoetanolamina, an experimental substance caused a great international repercussion and expos Brazil to an embarrassing situation. A governmental law, imposed the use of synthetic fosfoetanolamina for cancer treatment, without scientific bases for the confirmation of the effects and efficacy of anticancer treatment, by means of experimental laboratory studies and clinical trials. Thus the objective of this work was to evaluate the angiogenic activity/Antiangiogenic, mutagênica/antimutagênica this substance. The test of angiogenesis was performed using an experimental model (MCA) corioalantóide membrane of chicken egg. While the tests for mutagenicity and antimutagenicity, were performed by a micronucleus test in mouse bone marrow. The results were significant in all tests performed.