Avaliação dos parâmetros hematológicos, proteína C reativa e D-dímero em indivíduos infectados pelo SARS CoV-2

Abstract

During COVID-19, the hematopoietic system is affected and altered by the systemic infection caused by the virus. Throughout the course of the disease, neutrophilia, eosinophilia, thrombocytopenia, elevated levels of D-dimer and fibrinogen, as well as morphological changes in leukocytes, erythrocytes, and platelets can be observed. This study aims to analyze the main hematological alterations associated with SARS-CoV-2 infection, as well as C-reactive protein and D-dimer in individuals diagnosed with mild and severe COVID-19. This is cross-sectional analytical research using a sample of 40 individuals from Gurupi/TO, who have acute infection. The study participants were divided into two groups: 20 non-hospitalized patients (mild cases) and 20 hospitalized patients (severe cases). The data show that COVID-19 tends to manifest more severely in individuals over the age of 60. Furthermore, the levels of D-dimer and C-reactive protein increased significantly in individuals with severe COVID-19. Hemogram alterations were related to an increase in band neutrophils e segmented neutrophils in severe COVID-19 cases. Additionally, decreased values were found in red blood cells, hematocrit, and hemoglobin in severe COVID-19 cases. It is concluded that there is a clear abnormal pattern of hematological parameters in severe COVID-19 patients. Blood test results are relevant in the prognosis and monitoring of patients with COVID-19